We constructed a PLAUR-related ceRNA regulatory network in KIRC, namely the PVT1/SNHG15-hsa-miR-532-3p-PLAUR axis. In addition, the current study suggested that PLAUR might exert its tumorigenic effect by regulating tumor immune cell infiltration and immunomodulatory expression. The risk signatures derived from PRIs were independently predictive of OS for patients with KIRC and have potentially substantial clinical significance. This evidence concerns the gene PLAUR and neoplasm.