PLAUR and cancer: Based on TCGA database, we discovered that PLAUR was significantly upregulated in 11 cancer types, including BRCA, CHOL, COAD, ESCA, GBM, HNSC, KIRC, KIRP, STAD, THCA, and UCEC, as compared to that in normal tissues; however, the PLAUR mRNA was downregulated in two cancers, i.e., KICH and LUSC (P< 0.05) (Figure 1A).