MMP14 and neoplasm: In addition to our bioinformatics analysis of publicly available transcriptomic data suggesting the clinical relevance of MMP14 in association with tumorigenic cell lineages such as CAFs and TAMs to tumor recurrence, our single cell–based spatial profiling of the TME by mIHC analysis with a digital pathology platform allowed us to clarify that MMP14+ CAFs are a determinant of poor survival outcome in stage III colorectal cancer.