We didn’t identify the prognosis value of sPD-L1 in the present study although a few reports had addressed the association of sPD-L1 with the prognosis of patients, including the studies with contrasting result in lung cancer (6, 7) and no correlation in gastric cancer (17), worse prognosis in aggressive renal cell carcinoma and shorter survival in multiple myeloma and diffuse large B-cell lymphoma (9, 18). This evidence concerns the gene SPDL1 and AL amyloidosis.