Dr. Pan-Hammarström reported that genetic alterations in the PD-L1/PDL-2 locus are mainly associated with the non-GCB subtype of DLBCL, and translocations between PD-L1 and the IGH locus represent a genetic mechanism of PD-L1 overexpression in DLBCL (20). This evidence concerns the gene PDCD1LG2 and diffuse large B-cell lymphoma.