SPDL1 and metastatic malignant neoplasm in the lymph nodes: An univariate analysis showed that the level of sPD-L1 was significantly elevated in CRC group compared with the HC group, and sPD-L1 level in CRC group with lymph node metastasis is higher than in the CRC group without lymph node metastasis (all p<0.001, Figure 1).