LRP1 and cancer: For instance, in breast (33) and pancreatic (34) cancer models, the secretion of HSP90α in the tumor microenvironment and its specific binding to LRP-1 at the tumor cell surface was recently linked to the induction of common, but also distinct features, of an epithelial-to-mesenchymal transition in favor of metastatic dissemination and correlated to poor prognosis of cancer patients.