To achieve this goal, we used a validated method of invalidation of LRP-1 in FTC-133 thyroid carcinoma cells by siRNA (36) leading to a 70% decrease of its gene expression as evaluated by RT-qPCR (Figure 1A), and to a 66% decrease of its protein expression measured by western blot (Figure 1B). Here, LRP1 is linked to thyroid gland carcinoma.