Additionally, LRP-1 well documented function in the endocytic clearance of matrix proteases-containing complexes, including matrix metalloproteases (MMPs) (4), and plasminogen activators uPA and tPA (9–11), widely involved in invasive behavior of cancer cells, early pointed its crucial role in matrix remodeling events and designated its putative status of tumor suppressor (4, 12). The gene discussed is LRP1; the disease is cancer.