Based on the expression analysis of eight ephrin ligand genes (EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3) in 15,521 samples of 31 cancer types from TCGA and GTEx datasets, we found that EFNA1 expression was upregulated in 21 cancer types, including GBM, LGG, UCEC, BRCA, CESC, LUAD, ESCA, STES, COAD, PRAD, STAD, HNSC, KIRC, LIHC, BLCA, OV, PAAD, TGCT, ALL, LAML, and CHOL. The gene discussed is EFNB3; the disease is cancer.