In addition, we further investigated the potential relevance between ephrin family genes (EFNA3, EFNA4, EFNB1) and different immune subtypes of HCC, and the results revealed that the expression of EFNA3 and EFNA4 was prominently correlated with immune subtype (p = 5.23e-05, p = 1.68e-04, respectively). The gene discussed is EFNB1; the disease is hepatocellular carcinoma.