Our results suggest that EFNA3 and EFNA4 were negatively related to stromal and ESTIMATE scores but positively associated with tumor purity in HCC, which is consistent with the results obtained by Deng et al. (2021) in lung adenocarcinoma that EFNA3 is negatively associated with immunity and stromal infiltration. This evidence concerns the gene EFNA3 and lung adenocarcinoma.