ACSL4 (Du and Zhang, 2020; Feng J et al., 2021), SL7A11 (Tang B et al., 2020; Zhang et al., 2021), SLC3A2, and G6PD (Dai et al., 2021) are genes associated with ferroptosis in HCC with clear prognostic significance. The gene discussed is ACSL4; the disease is hepatocellular carcinoma.