IL6 and injury: Knockdown of MALAT1 upregulates NF-κB and IL-6 expression in renal ischemia-reperfusion injury (Tian et al., 2018), but also inhibits IL-1β, IL-6 and TNF-ɑ production in Lipopolysaccharide (LPS)-induced acute lung injury (Dai et al., 2018), suggesting a duel function of this lncRNA in inflammatory regulation.