TF and neoplasm: TF/FVIIa complex acts into protease activated receptor 2 (PAR-2) (Schaffner and Ruf, 2009), which in turn activates a number of downstream signaling involved in the production of pro-angiogenic factors, immune-modulatory cytokine and growth factors that supports tumor cell migration and metastasis (Unruh and Horbinski, 2020).