This approach was also applied using Ixolaris, a specific TF inhibitor from Ixodes scapularis (Francischetti et al., 2002), in an orthotopic glioblastoma (GBM) model in mice treated with a technetium-99 (99mTc) radiolabeled-Ixolaris (Barboza et al., 2015). Here, TF is linked to glioblastoma.