EGF and corneal ulcer: Because EGF, which is present in tear film, is known to be safe and effective in reducing the healing time of corneal ulcers, we used an acute alkali burn rat model to compare the corneal healing effects of bleogen pB1 and EGF (Daniele et al., 1979; Singh and Foster, 1987; Pastor and Calonge, 1992; Van Setten et al., 1994).