EGF and corneal ulcer: Previous studies have also demonstrated the importance of EGFR activation for the EGF-mediated corneal epithelial wound healing in various animal models (Singh and Foster, 1987; Zieske et al., 2000; Peterson et al., 2014), as well as the potential clinical use of EGF for the management of corneal ulcers in humans (Daniele et al., 1979; Pastor and Calonge, 1992).