In older 3xTg AD mice (14 months-old), Lonafarnib infusions effectively reduced the number of dense-core amyloid plaques that overlapped with MC1 immunolabelling (Supplementary Figures S9, S12) in dSub as compared to vehicle infused mice (t14 = 3.86, p = 0.0017, unpaired two-tailed t-test; Figures 2E–G). Here, ATP7A is linked to Alzheimer disease.