Neuropathology in AD patients is characterized by extracellular deposits of aggregated amyloid-β (Aβ; i.e., amyloid plaques), and neurofibrillary tangles (NFTs) consisting of hyperphosphorylated tau, and eventually abiotrophic neuronal cell death starting in superficial layers of lateral entorhinal cortex (LEC) (Braak and Braak, 1991; Thal et al., 2002; De Strooper and Karran, 2016). Here, MAPT is linked to Alzheimer disease.