Tet downregulates this signaling pathway and inhibits proliferation and invasion of glioma U87 cells (Wu et al., 2014), and also promotes PI3K/Akt/mTOR signaling pathway-mediated cell apoptosis and exert anti-gemcitabine-resistant pancreatic cancer effects (Song et al., 2021a). This evidence concerns the gene AKT1 and pancreatic neoplasm.