Qin et al. (2018) established a rat model of migraine and found that Tet pretreatment inhibited S100B and p-ERK activation in satellite glial cells of the trigeminal ganglion and attenuated injury perception in rats. In a model of joint inflammation, Tet reduced foot swelling, bone erosion, immunosuppression, and reduced inflammation in a rat model of arthritis and rheumatoid arthritis (Gao et al., 2016a; Jia et al., 2018; Li et al., 2018). The anti-inflammatory effects and anti-inflammatory molecular mechanisms of Tet are comprehensively summarized in Figure 2 and Table 2. Here, S100B is linked to Arthritis.