In almost all solid cancers, the tumor microenvironment is characterized by an immunosuppressive milieu, due to the secretion of specific molecules (e.g., IL-10 and IFN-γ) (Sarvaria et al., 2017; Labani-Motlagh et al., 2020) and the exploitation of IC functions, allowing cancer cells to escape immune surveillance, thus leading to cancer progression and patient prognosis worsening. This evidence concerns the gene IFNG and cancer.