N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) restores the expression of sirt3 and ameliorates fibrosis in DN (Srivastava et al., 2020a), an effect that was found to be partially dependent on FGFR1 (Li et al., 2020). Here, SIRT3 is linked to liver dysplastic nodule.