N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) restores the expression of sirt3 and ameliorates fibrosis in DN (Srivastava et al., 2020a), an effect that was found to be partially dependent on FGFR1 (Li et al., 2020). The gene discussed is FGFR1; the disease is liver dysplastic nodule.