Sirt1 can deacetylate regulated STAT3, p53, FOXO4 and PGC1-α to maintain podocyte function (Nakatani and Inagi, 2016), and activation of sirt1 promotes the expression of PGC1-α in podocytes, thereby ameliorating podocyte injury and proteinuria in DN (Hong et al., 2018). Here, PPARGC1A is linked to liver dysplastic nodule.