Jiang et al. (2021) found that sirt1 knockout aggravated NLRP3 inflammasome activation in a mouse model of aldosterone infusion, and a recent report also found that sirt1 blunted NLRP3 inflammasome activation via autophagy to ameliorate IgA nephropathy (Wu et al., 2020). Here, SIRT1 is linked to IgA glomerulonephritis.