“Calorie restriction,” “autophagy,” and “acetylation,” as the keywords with the strongest citation bursts, indicate major areas in the study of sirt1 in kidney disease, and “autophagy” and “NLRP3 inflammasome” also represent emerging areas in the past 5 years in the study of sirt1 in kidney disease. The gene discussed is NLRP3; the disease is kidney disorder.