In the past 5 years, the publication by Liu R et al. in Diabetes in 2014 showed the strongest beginning of citation burst and found that transcription factors, such as p65 and STAT3, acetylation plays an important role in DN (Liu et al., 2014), followed by an article in JASN published by Morigi M et al. in 2018, who reviewed the central role of sirt1 in kidney health and disease (Morigi et al., 2018). The gene discussed is SIRT1; the disease is liver dysplastic nodule.