RarLy-stimulated WB from COVID-19 patients revealed trends of increased Th-cell exhaustion compared to controls, with MMRs of 1.47, 1.33, 1.32, and 1.22 for PD-1+ Th, PD-1 MFI on Th, PD-1+ RarLy-reactive cells, and PD-1 MFI on RarLy-reactive cells, respectively (Figures S6C-F). The gene discussed is PDCD1; the disease is COVID-19.