SECOND LINE OPTIONSPrednisolone +MMF 1200 mg/m2/dayIf DNT ↑: Prednisolone + Sirolimus 1–2.8 mg/m2/dayNotes:Wean off prednisolone after 4 weeksWean off MMF after 6-12 months > 3-6 monthsIf successful, keep dosage as low as possibleIf signs of CID: consider targeted therapy, HSCTRituximab 375 mg/m2 once per week, 4 times especially in case of: chronic EBV infection, high CD19+frequencyMethylprednisolone 10–30 mg/kg/d for 3 daysDexamethasone 5–10 mg/m2 > 4 d. Here, CD19 is linked to Epstein-Barr virus infection.