Despite the high level of Ifng expression, intestinal NCR+ ILC3s produce minimal IFNγ at a steady state in WT mice or after ex vivo restimulation with IL-12, IL-18 and PMA/ionomycin with brefeldin A (55, 60, 90), but NCR+T-bet+ ILC3s appear poised for IFNγ production as part of the innate defense against infection (91). Here, IFNG is linked to infection.