A recent prospective study including 216 cases of acute myeloid leukemia (AML) showed that the number of MAIT cells in PB from newly diagnosed AML was significantly reduced, and the degree of reduction was associated with a high-risk cytogenetic karyotype and IDH1/2 mutation, suggesting that the loss of MAIT cell number or function may be associated with AML disease progression (103). The gene discussed is IDH1; the disease is acute myeloid leukemia.