MoMFs, key effector cells in the hepatic immune activities, are derived from infiltrated bone marrow-derived CCR2+CX3CR1loLy6Chi monocytes, whose recruitment is dependent on the CCL2-CCR2 axis (195, 196), which has been well-recognized in plenty of liver diseases including liver fibrosis and hepatic carcinoma. The gene discussed is CCL2; the disease is Hepatic fibrosis.