CXCR3 and Hepatic fibrosis: In the Schistosoma japonicum infection caused liver fibrosis model, dynamic changes of lymphocyte populations in the spleen and concurrent upregulation of chemokines and cell adhesion molecules in the liver also suggested a recruitment of active immune cells from spleen to the liver (74), among which CXCR3+ Tregs were supposed to occupy a considerable proportion of the lymphocytes that migrate from spleen to Th1-infiltrated liver tissues to regulate liver fibrosis (75).