TGFB1 and Hepatic fibrosis: Several experimental studies have demonstrated that removal of the spleen accelerates liver regeneration and inhibits the development of liver fibrosis  (71, 87–89), indicating a certain role of the spleen in liver regeneration. TGF-β is recognized as the critical factor in the performance of spleen to inhibit liver regeneration in both the thioacetamide-induced liver fibrosis rat model (90) and the partial hepatectomy rat model (91). Upon injury, the liver goes through a process from initiation and proliferation to resolution and repair.