Our findings correlate well with previously reported data suggesting that Bregs (CD19+IL10+) mostly had the CD27- phenotype in HD and MS patients in remission (28), whereas the percentage as well as the absolute counts of memory Bregs (CD24highCD27+) and naïve and memory B cells were similar in the HDs and MS patients (Figure 4B; Table 3). Here, CD27 is linked to Huntington disease.