IL6 and infection: Of the principal components obtained from PCA that correspond to cytokines, IL-10 (32.5 pg/mL from naïve and 29.3 pg/mL from pre-infected average concentration), IL-12p70 (28.9 pg/mL from naïve and 29.4 pg/mL from pre-infected average concentration), and IL-6 (62.5 pg/mL from naïve and 64.0 pg/mL from pre-infected average concentration) showed significant differences (p ≤ 0.005) (Figure 4), the concentration is higher in individuals with an infection before vaccination.