To further understand the structure and gene alteration of the OTUD6B gene, we used the cBioPortal database to explore the genetic alterations in OTUD6B and observed a high frequency of genetic alterations in patients with BRCA, UCS, PRAD, and LIHC, while patients with THCA, mesothelioma (MESO), KIRP, acute myeloid leukemia (ACC), and thymoma (THYM) possessed no gene alteration. The gene discussed is OTUD6B; the disease is mesothelioma.