Sorafenib can interfere with the above cellular signal transduction pathways, play a direct antitumor role in inhibiting the activities of c-Raf (Raf-1) and B-Raf, and play a dual antitumor role in antagonizing VEGFR-1,2,3 inhibiting the formation of tumor-related neovascularization. This evidence concerns the gene FLT1 and neoplasm.