MYCN and diffuse intrinsic pontine glioma: PA blockade therapy (AMXT1501/DFMO) using difluoromethylornithine (DFMO), an ornithine decarboxylase inhibitor, and AMXT1501 (31, 61), a PA transport inhibitor, demonstrates excellent responses in diffuse intrinsic pontine glioma (62) or MYCN transgenic mice models (31).