After a sequence of analysis, we observed a statistically positive correlation between cancer-associated fibroblasts and FAT4 expression in the TCGA tumors of ACC, BLCA, BRCA (BRCA–Basal, BRCA–LumA), CESC, COAD, ESCA, HNSC (HNSC–HPV–, HNSC–HPV+), LIHC, LUAD, LUSC, MESO, OV, PAAD, PRAD, READ, SARC, SKCM (SKCM–Metastasis), STAD, TGCT, and UCEC (Figure 6). Here, FAT4 is linked to cancer.