Moreover, Th1 cells, Th17 cells, ILC1s, ILC3s, and M1 macrophages are involved in this endotype, and their production IL‐1β, IL‐6, IL‐17, IFN‐γ, and TNF‐α are responsible for the recruitment and activation of inflammatory cells during asthma attacks. The gene discussed is IL1B; the disease is asthma.