The relative mRNA expression of inflammatory factors in skin lesions showed that interferon-γ (Ifn-γ), tumor necrosis factor-α (Tnf-α), thymic stromal lymphopoietin (Tslp) and Il-4 were significantly increased in DNCB-induced AD mice, and the relative mRNA expressions of Ifn-γ, Tnf-α, Tslp and Il-4 were significantly decreased after POAE and POEE treatments (Figures 5C–F). The gene discussed is IL4; the disease is Alzheimer disease.