The PCOS-enriched vOTUs encoded functions, such as integrase/recombinase (K04763), ATP-dependent protease (K01358), RNA polymerase sigma-70 factor (K03088), starch-binding outer membrane proteins (K21572/K21573), and thymidylate synthase (K00560), while the control-enriched vOTUs encoded more functions involving single-stranded DNA-binding protein (K03111), site-specific DNA recombinase (K06400), chromosome-partitioning protein (K03497), integrase (K14059), 5-methylcytosine-specific restriction enzyme (K07451), and DNA primase/helicase (K06919; Supplementary Table S3). This evidence concerns the gene RPA1 and polycystic ovary syndrome.