CDK4 and B-cell non-Hodgkin lymphoma: Analysis of human non-Hodgkin B-cell lymphoma specimens showed that CDK4 protein expression is down-regulated in several sub-types, which correlated with reduced levels of CDK4 transcripts, pointing to a tumor-suppressive role for CDK4 in MYC-driven B-lineage malignancies via suppression of genomic instability.