Interestingly, five of these loci, i.e., ACTN1, PDS5B, SEMA6D, SPRY4, and TENM3, have been reported of association with the genetic susceptibility of asthma (Yucesoy et al., 2015; Almoguera et al., 2017; Demenais et al., 2018; Olafsdottir et al., 2020). The gene discussed is SPRY4; the disease is asthma.