So, to inhibit the expression of PLK4 either by the PLK4 inhibitor or lentivirus-mediated knockdown in the AML cell lines would help us to clarify roles and mechanisms of PLK4 in the leukemiagenesis of AML, and thus provide clues in whether PLK4 was a potential target for AML clinical treatment and therapy. The gene discussed is PLK4; the disease is acute myeloid leukemia.