RHOT1 and neoplasm: In fact, previous studies have reported that miR-326 was a tumor inhibitor in lung cancer, which inhibited lung cancer metastasis, growth and chemotherapy resistance by HOTAIR/miR-326/phoox2a pathway, miR-326/ZEB1 pathway and RHOT1/miR-326/FOXM1 pathway (Wang et al., 2016; Liu et al., 2021; Zhang et al., 2021).