Harari-Steinfeld et al. (2021) found that lncRNA H19-derived microRNA-675 promotes liver necroptosis by targeting FADD. Wang et al. (2020) found that ammonia regulates chicken tracheal cell necroptosis via the lncRNA-107053293/miR-148a-3p/FAF1 axis. Although several NRL signatures of cancer have been reported (Wang and Liu, 2021; Zhao et al., 2021), there is no study associated with NRL signatures of pancreatic cancer. This evidence concerns the gene H19 and familial pancreatic carcinoma.