Balastik et al. found that TRIM2 binds to neurofilament light subunit (NF-L) and regulates its ubiquitination; furthermore, they showed that TRIM2-deficient mice exhibit accumulation of NF-L in neuronal structures, which leads to axonal diseases, progressive neurodegeneration, tremors, and the onset of ataxia at a young age [20]. Here, NEFL is linked to cerebellar ataxia.