Through gene set enrichment analysis (GSEA), lower TRIM2 expression was found to be associated with the G2/M checkpoint, EMT, hypoxia pathway, and Myc signaling gene sets, and TRIM2 was speculated to possibly play a negative role in regulating cell cycle progression, EMT, and Myc signaling pathways in ccRCC. This evidence concerns the gene MYC and nonpapillary renal cell carcinoma.