TNF and rheumatoid arthritis: KEGG pathway analysis revealed that the module 1 was mainly enriched during IL-17 signaling pathway, inflammatory bowel disease, rheumatoid arthritis, allograft rejection, T cell receptor signaling pathway, cytokine-cytokine receptor interaction, intestinal immune network for IgA production, JAK-STAT signaling pathway, TNF signaling pathway, etc. (Figure 8).