Pelengaris et al. reported that overexpression of C-Myc disrupted the differentiation of keratinocytes in the epidermis and that cSCC showed enhanced levels of proliferation and disruption of the differentiation process, results which are consistent with the concept of a “tumor MYC addiction.” MYC activation represents one of the events required for the initiation of tumorigenesis, which implies that tumor survival is dependent on high levels of MYC [30] and the hypothesis that tumor survival is dependent on increased MYC levels. Here, MYC is linked to neoplasm.