We have previously demonstrated that depletion of Qk (mouse gene encoding Quaking) along with tumor suppressors Trp53 and Pten in neural precursor cells (NSCs) using Nestin-CreERT2 system (QPP) led to GBM formation in mice with a penetrance of over 90%, providing a novel and reliable system to study GBM (Shingu et al., 2017). The gene discussed is PTEN; the disease is glioblastoma.