GSK3B and early-onset autosomal dominant Alzheimer disease: However, studying GSK3β activity in post-mortem human tissues is difficult and similar analyses of GSK3β in post-mortem Alzheimer’s disease brains have generated highly conflicting data with some reporting increased and some decreased activity in Alzheimer’s disease (Ferrer et al., 2002; Swatton et al., 2004; Leroy et al., 2007).