The curation and mapping of DEGs was done using different databases such as PubMed, OMIM, MeSH, and PMC giving the following potential type 2 diabetes mellitus-associated genes: MCL1, PTX3, CYP3A4, PTGS1, SSTR2, SERPINA3, TDO2, and GALNT7. The function of these signature genes was curated and counted. This evidence concerns the gene PTGS1 and type 2 diabetes mellitus.