Using multivariable Cox proportional hazard regression models, the ID pain score was a significant predictor for total mortality with an HR of 1.394 (95% CI: 1.090−1.782, P = 0.008; Table 3), and the DN4 was also a significant predictor for total mortality with an HR of 1.668 (95% CI: 1.211−2.297, P = 0.002; Table 3) after adjusting for age, sex, hypertension, CAD history, diabetes duration, HbA1c level, HDL cholesterol level, CKD, the UACR, and the use of antiplatelet drugs, antihypertensive drugs, insulin, and metformin. The gene discussed is INS; the disease is diabetes mellitus.