MTHFD2 and non-small cell lung carcinoma: Because the physiological function of MTHFD2 is catalyzing 5,10-methyl-lenetetrahydrofolate to 10-formyltetrahydrofolate along with NAD(P)+ to NAD(P)H, we proposed that MTHFD2 could promote NSCLC progression by regulating reductive/oxidative (redox) processes.