The majority of transcripts show a reduced m6A methylation upon infection such as TMED2, while a few show increased methylation, such as the proto-oncogene JUNB, a key transcriptional modulator of macrophage activation (Fontana et al., 2015) and the immediate early response IER3, involved in cellular stress response and inflammation (Arlt and Schäfer, 2011). The gene discussed is IER3; the disease is infection.