The bacterial lysate OM–85 has been extensively investigated, and it has shown to enhance deficient INF responses (Dang et al., 2017) to modulate the interplay between Th1 and Th2 mechanisms (Huber et al., 2005) and to potentially play a role in gut microbiota rearrangement (Rossi et al., 2019). This evidence concerns the gene CBLIF and ocular melanoma.