Knowing the mechanism of capsaicin in neutralizing TRPV1 upregulation, we designed a pilot investigation to primarily assess its safety in patients with SCD, as well as to explore its utility as a mechanistic probe in isolating the role of peripheral TRPV1 receptors in human SCD‐related pain toward future construction of a more detailed cause‐and‐effect model of chronic pain in SCD. The gene discussed is TRPV1; the disease is Schnyder corneal dystrophy.