Recent studies have highlighted the role of mir‐125 in leukaemogenesis and haematopoietic stem cell (HSC) self‐renewal in Mixed Lineage Leukaemia (MLL)‐translocated AML, whereby miR‐125a overexpression upregulated vascular endothelial growth factor A (VEGFA) and was associated with a significantly reduced median survival in MLL/miR‐125 transduced mice. The gene discussed is KMT2A; the disease is acute myeloid leukemia.