Next generation sequencing (NGS) for myeloid neoplasms revealed a variant of unknown significance (SH2B3: Chr12(GRCh37): g.111886029C > T; NM_005475.2(SH2B3): c.1651C > T; p.Arg551Trp (49%)). This evidence concerns the gene SH2B3 and myeloid neoplasm.