All cases of high grade DLBCL with karyotype and FISH ascertained during 2005–2020 (31 MYC+: 13 bone marrow, seven lymph nodes, nine other tumor site; 28 MYC−: eight bone marrow, 11 lymph nodes, eight other tumor site, tumor site not available for three cases) were included in the study. The gene discussed is MYC; the disease is neoplasm.