To help further manage bleeding and in preparation for upcoming splenectomy with consideration of AVWS and the weak anti‐VWF IgG suggestive of a possible immune‐mediated mechanism and moderate possibly immune thrombocytopenia (ITP), a 4‐day trial of pulse dexamethasone and two doses of intravenous immunoglobulin were given. This evidence concerns the gene VWF and autoimmune thrombocytopenic purpura.