By comparing colonic mRNA levels of various BARs in colitis animals, most BARs levels were increased in PCDSS mice (Figure S5a), such as Gpbar1(TGR5), Vdr, Nr1h3 (LXRα), Nr1h2 (LXRβ), Nr1i2 (PXR), and Nr1i3 (CAR). This evidence concerns the gene GPBAR1 and colitis.