MB would be administered through the catheter and eventually mix with Hb to enhance the visualization of target structures in vascular pathologies (e.g., atherosclerositic plaques,55 thrombi,56 tumor neovasculatures,57,58 and endothelia59), and the local concentration of MB versus Hb would be monitored with our proposed method with either external54 or intravascular60 ultrasound sensor placement. This evidence concerns the gene GSTM1 and neoplasm.