LDLR and metabolic syndrome: Single-nucleotide polymorphisms (SNPs) in APO and LDLR genes, such as rs3135506 (APOA5), rs1042034 (APOB), rs2854116 (APOC3), rs429358 (APOE), and rs2228671 (LDLR) have been associated with dyslipidemia, including elevated cholesterol, triglycerides, or both along with increased LDL cholesterol (LDL-C) or decreased HDL cholesterol (HDL-C) levels in the circulation [14, 22, 24–26].